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Immunizations
Stay protected with CDC-recommended vaccines including flu shots, COVID-19, shingles, and more.
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- ServicesImmunizationsStay protected with CDC-recommended vaccines including flu shots, COVID-19, shingles, and more.Free DeliveryGet your prescriptions delivered to your home or office in Simpsonville for free.Multi-Dose Pill Packaging (Compliance/Dispill)Simplify your health with $5 multi-dose pill packaging at Charlie's Hometown Pharmacy.Medication Therapy Management (MTM)Personalized Medication Therapy Management to optimize your health and results.Medication Adherence & Med SyncSync your prescriptions for a single monthly pickup and stay on track with your health.Diabetes Care CenterManage your diabetes with expert guidance, local care, and personalized support.Over The Counter & LEADER™ ProductsShop high-quality LEADER™ over the counter products and health essentials.Prior Authorization AssistanceExpert help navigating insurance approvals for medications in Simpsonville.Medicare Part D & Open EnrollmentExpert guidance on Medicare Part D and Open Enrollment.Men's health and Erectile DysfunctionDiscreet and affordable Men's Health and Erectile Dysfunction solutions in Simpsonville.Curbside PickupSave time with convenient curbside pickup. Get your prescriptions without leaving your car.Cash Discount PlanSave money on prescriptions with our affordable Cash Discount Plan.12 services availableView all services
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Charlie’s Hometown Pharmacy in Simpsonville: Top-Notch Care and Personalized Service
The Pharmacy That Actually Takes Time for You in Simpsonville, SC
At Charlie's Hometown Pharmacy, you get more than a prescription. You get a pharmacist who grew up right here in Simpsonville, knows your name, and takes the time to answer your questions.
Located at 508 SE Main St, steps from Prisma Health Hillcrest Hospital, we're locally owned and proud to serve Simpsonville, Greenville, and Fountain Inn.
Personal care from a pharmacist who knows your name
Charlie Brainard, RPh, PharmD, is a lifelong Simpsonville resident. When you walk in, you're a neighbor, not a number.
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Services
More Than Prescriptions: Clinical Services and Personalized Support
From immunizations and medication therapy management to diabetes care, free delivery, and blister pack packaging, Charlie's Hometown Pharmacy brings full-service clinical care with the personal attention only a locally owned pharmacy can deliver.
About Us
Charlie's Hometown Pharmacy on SE Main Street, Simpsonville
Locally Owned
Owned and operated by Charlie Brainard, RPh, PharmD, a lifelong Simpsonville resident and University of South Carolina graduate. Charlie opened this pharmacy to give his community a pharmacist who truly cares, and over 1,000 patients have already made the switch.
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Where Pharmacy Feels Personal Again
Locally owned by a lifelong Simpsonville resident, Charlie's brings ACHC-accredited care, PCCA-certified compounding, and genuine patient relationships to Simpsonville, Greenville, and Fountain Inn. No corporate decisions, no rotating staff. Just a pharmacy built around the neighbors who walk through its doors.
Charlie's Hometown Pharmacy was built on a simple idea: your pharmacist should know who you are, not just your prescription number.
Immunizations at Charlie's Hometown Pharmacy
Your Vaccination, Your Way
Charlie Brainard is a Certified Immunization Pharmacist (CIP). From flu shots and shingles vaccines to COVID-19 and travel immunizations, get the protection you need right on SE Main Street in Simpsonville.
Walk-Ins Welcome
No appointment needed for most vaccines. Stop by during pharmacy hours and we'll take care of you on the spot.
All Major Insurance Accepted
Most insurance plans cover vaccinations at no cost to you. We verify your coverage before you leave.
Book Online Anytime
Prefer to schedule ahead? Use the Quick Rx app to book your vaccination appointment at a time that works for you.
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Quick Rx App
Skip the Phone Call, Open the App
The Quick Rx app puts your pharmacy on your phone. Refill prescriptions, transfer medications, and schedule appointments, all without waiting on hold. Download free on iOS and Android.
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Refill and Transfer in Seconds
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Set Custom Dose Reminders
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HIPAA-Secured Information
One-Tap Refills
Select your medication, tap refill, and your prescription will be ready for pickup. No phone calls, no standing in line, no guesswork.
Never Miss a Dose
Set personalized reminders for each of your medications and get a notification when it's time to take them. Staying consistent with your prescriptions has never been easier.
Ready to transfer your Rx?
Give us a call: (864) 665-5001
Pharmacy Hours
Mon-Fri: 09:00 AM - 6:30 PM, Sat: 10:00 AM - 3:00 PM, Sun: Closed
Explore Our Services
Best Care With 5 Star
10k+ Happy Patients
TESTIMONIALS
Our Patients Share Their Outstanding Experiences
Neighbors in Smith County count on us for fast prescriptions and a friendly team that listens. We are grateful for the trust you place in Smith County Drug Center Pharmacy.
Charly and staff are not just nice but very empathetic with their clients and really cares to build relationships with them very knowledgeable and great prices. Thank you for exiting
SS
Sonia S.
Charlie’s pharmacy is literally the best. They’re quick and don’t just treat you like a number. Better than any pharmacy around.
JS
Jordan S.
Had to make a quick stop for some OTC medication, I was pleasantly surprised by the friendly and caring environment. I highly recommend this pharmacy for your RX needs.
JD
Jessica D.
This place is the best from top tier customer service, prompt with filling my order, and the most important of all, finding cost savings. Definitely a great hometown pharmacy.
JM